Scientific Advisory Board
Drew Pardoll, MD, PhD
Abeloff Professor of Oncology, Medicine, Pathology and Molecular Biology and Genetics, Johns Hopkins University, School of Medicine; Director of the Cancer Immunology, Sidney Kimmel Comprehensive Cancer Center.
Dr. Pardoll attended Johns Hopkins University, where he earned his MD, PhD, in 1982 and completed his medical residency and Oncology Fellowship in 1985. He then worked for three years at the National Institutes of Health as a Medical Staff Fellow. Dr. Pardoll joined the departments of oncology and medicine in 1988. Dr. Pardoll has published over 300 papers as well as over 20 book chapters on the subject of T cell immunology and cancer vaccines. He has served on the editorial board of the Journal of the National Cancer Institute and Cancer Cell, and has served as a member of scientific advisory boards for the Cancer Research Institute, the University of Pennsylvania Human Gene Therapy Gene Institute, Biologic Resources Branch of the National Cancer Institute, Harvard-Dana Farber Cancer Center, Cerus Corporation, Global Medical Products Corporation, Genencor Corporation, CellGenesys Corporation, Mojave Therapeutics, the American Association of Clinical Oncology and the American Association of Cancer Research. Dr. Pardoll has made a number of basic advances in cellular immunology, including the discovery of gamma - delta T cells, NKT cells and interferon-producing killer dendritic cells. Over the past two decades, Dr. Pardoll has studied molecular aspects of dendritic cell biology and immune regulation, particularly related to mechanisms by which cancer cells evade elimination by the immune system. He is an inventor of a number of immunotherapies, including GVAX cancer vaccines and Listeria monocytogenes based cancer vaccines. Dr. Pardoll’s basic immunology discoveries include the identification of gd-T cells, NKT cells and IKDC. He elucidated the role of Stat3 signaling in tumor immune evasion and in Th17 development, leading to the discovery that Stat3-driven Th17 responses promote carcinogenesis. Dr. Pardoll discovered one of the two ligands for the PD-1 inhibitory receptor and leads the Hopkins cancer immunology program that developed PD-1 pathway-targeted antibodies, demonstrating their clinical activity in multiple cancer types. His more than 300 articles cover cancer vaccines, gene therapies, cancer prevention technologies, recombinant immune modulatory agents for specific pathways that regulate immunity to cancer and infectious diseases.
Jedd D. Wolchok, MD, PhD
Lloyd J. Old/Virginia and Daniel K. Ludwig Chair in Clinical Investigation, Chief, Melanoma & Immunotherapeutics Service, Associate Director, Ludwig Center for Cancer Immunotherapy, Associate Member, Ludwig Cancer Research, Professor of Medicine, Weill Medical College of Cornell University, Memorial Sloan-Kettering Cancer Center.
Dr. Wolchok is Chief of the Melanoma and Immunotherapeutics Service and holds The Lloyd J. Old Chair in Clinical Investigation at Memorial Sloan Kettering Cancer Center (MSKCC) with an expertise in the treatment of metastatic melanoma. His additional appointments include: Head of the Swim Across America - Ludwig Collaborative Laboratory; Associate Director of the Ludwig Center for Cancer Immunotherapy (LCCI). He has helped establish MSKCC as a leader in the discovery and treatment of cancers with novel immunotherapies.
Dr. Wolchok was instrumental in the clinical development leading to the approval of ipilimumab for advanced melanoma. He is principal investigator of numerous ongoing clinical trials at MSKCC in the area of immunotherapy. He supervises an R01-funded basic science laboratory which is focused on investigating novel immunotherapeutic agents in pre-clinical mouse models. In 2011, he established the Immunotherapeutics Clinical Core, a specialized phase 1-2 outpatient unit at MSKCC that is focused on the conduct of novel immunotherapy trials, with a specific emphasis on pharmacodynamic biomarker identification. This group treats patients with a broad spectrum of malignancies.
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Dario Vignali, PhD
Vice Chair and Professor of Immunology, Department of Immunology, University of Pittsburgh School of Medicine; Co-Leader of the Cancer Immunology Program, University of Pittsburgh Cancer Institute (UPCI), Hillman Cancer Center.
Dr. Vignali’s labs focus on analysis of immune cell function in mouse model systems and disease models of cancer and autoimmune disease, and on inhibitory immune pathways in human cancers. Dr. Vignali’s research findings have been published in some of immunology’s leading journals, and he has been awarded five patents worldwide with several more awaiting approval. He also is a current member of the scientific advisory boards at two biopharmaceutical companies.
Since 1993, Dr. Vignali worked at St. Jude Children’s Research Hospital in Memphis, Tennessee, and served as vice-chair of its immunology department since 2008. He taught in the Department of Pathology at the University of Tennessee Medical Center since 1996.
He received his undergraduate education at North East London Polytechnic, now East London University, and completed his doctoral studies at the London School of Hygiene and Tropical Medicine at the University of London. Dr. Vignali completed two postdoctoral fellowships, one at the Institute for Immunology and Genetics at the German Cancer Research Center in Heidelberg, Germany, and the second in the Department of Biochemistry and Molecular Biology at Harvard University.
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Charles G. Drake, MD, PhD
Co-Director, Cancer Immunotherapy Programs, Professor of Medicine, Director of Genitourinary Oncology, Associate Director for Clinical Research, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center.
Charles George Drake, MD, PhD, is a professor of oncology and immunology at the Columbia University Herbert Irving Comprehensive Cancer Center, where he directs the Genitourinary Cancer Program, and co-directs the Immunotherapy Program. Additionally serving as the associate director for clinical research in the Irving Cancer Center, Dr. Drake’s areas of expertise include basic and translational cancer immunology, and the treatment of genitourinary cancers.
With degrees in electrical and biomedical engineering, Dr. Drake earned a PhD in immunology from the National Jewish Center for Immunology. He completed an MD at the University of Colorado Health Sciences Center. Following a residency in internal medicine on the Osler Service and a fellowship in medical oncology, both at Johns Hopkins, Dr. Drake joined the Johns Hopkins faculty. He moved to Columbia University in 2016.
Dr. Drake has published extensively, winning awards and honors for his research and scholarship. He holds several patents, several of which have been translated to patients in Phase I clinical trials. His laboratory focuses on understanding the immune response to cancer, using both cutting-edge animal models and patient samples.
Lab web page
Vijay Kuchroo, DVM, PhD
Co-Director of the Center for Infection and Immunity, Samuel L. Wasserstrom Professor, Department of Neurology, Associate Member, Broad Institute; Director, Evergrande Center for Immunologic Diseases, Harvard Medical School.
Dr. Kuchroo currently holds a title of Professor of Neurology at the Harvard Medical School and Associate Immunologist at the Brigham and Women's Hospital, Boston. Dr. Kuchroo has published over 340 original papers and numerous review articles. Dr. Kuchroo's major research interests are studying the autoimmune diseases, particularly the role of co-stimulation (Cell; 80: 707-18,1995), genetic basis of EAE and type 1 diabetes (Nature Genetics, 21: 158-161, 1999) and cell surface molecules and regulatory factors (Nature 2002. 415:536-41; Nature Immunol. 2003 4:1102-10. ) that contribute to susceptibility and resistance to autoimmune diseases. Dr. Kuchroo's laboratory has made several transgenic mice that serve as animal models for human disease (Proceedings National Academy of Sciences USA, 97: 3412-3417, 2000; J Exp Med. 2003; 5;197:1073-81 ). Dr. Kuchroo is on the Editorial Boards of the journals: Journal of Experimental Medicine, International Immunology, Scandinavian Journal of Immunology, Cellular Immunology and an ad hoc reviewer for a number of Immunology related journals. He was a permanent member of the grants review board of the Juvenile Diabetes Research Foundation, New York and scientific review board of the National Multiple Sclerosis Society, New York. Dr. Kuchroo is also an ad hoc reviewer for the research grants for various study sections at the National Institutes of Health. Based on his contributions, Dr. Kuchroo was awarded the Javits Neuroscience Award by the National Institutes of Health in 2002 and Ranbaxy Prize, 2011. Dr. Kuchroo is the first incumbent of the Samuel L. Wasserstrom Chair in Neurology at Harvard Medical School. Dr. Kuchroo is an inventor on 25 patents and has been a founder of 5 different start-up biotech companies. Dr. Kuchroo is on the scientific advisory boards of Pfizer, Glaxo Smith Klein and Novartis.
Dr. Vijay K. Kuchroo obtained a degree in Veterinary Medicine from the School of Veterinary Medicine, Hisar, India. He obtained a Ph.D. in Pathology from the department of veterinary pathology at the University of Queensland, Brisbane (Australia). Dr. Kuchroo received the Fred Z. Eager Research prize and medal for his Ph.D. research work at the University of Queensland. He served as Fogarty International Fellow at the National Institutes of Health, Bethesda for a year before joining the Department of Pathology, Harvard Medical School as a Research Fellow in the fall of 1986. Dr. Kuchroo joined the Center for Neurologic Diseases, Brigham and Women's Hospital in 1992.
Lab web page
Ana Carrizosa Anderson, PhD
Assistant Professor of Neurology, Harvard Medical School, Associate Scientist, Brigham and Women’s Hospital, Boston.
Dr. Anderson obtained her PhD in Immunology from Harvard University in 1999. During her PhD she was awarded a fellowship from the Howard Hughes Medical Institute. Dr. Anderson works in the field of cancer immunology, specifically on the role of inhibitory molecules in regulation of the anti-tumor T cell response. Her laboratory identified the inhibitory molecule Tim-3 as a key regulator of T cell dysfunction in cancer. Prior to working in the field of cancer immunology, Dr. Anderson worked in the field of autoimmunity. Dr. Anderson has published over 38 original papers, 12 reviews, and 5 book chapters. Her work on T cell cross-reactivity in autoimmunity was selected by Nature Immunology as a ‘Classic Paper in Autoimmunity’. She has also had several papers selected as either ‘must-read’ or ‘recommended’ by the Faculty of 1000. Dr. Anderson is a core faculty member of the Evergrande Center for Immunologic Diseases and serves on the editorial board for OncoImmunology and Cellular Immunology. She recently served on the scientific advisory board for CoStim Pharmaceuticals, Inc., which was recently acquired by Novartis.